A structural view of microRNA–target recognition

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A structural view of microRNA–target recognition

It is well established that the correct identification of the messenger RNA targeted by a given microRNA (miRNA) is a difficult problem, and that available methods all suffer from low specificity. We hypothesize that the correct identification of the pairing should take into account the effect of the Argonaute protein (AGO), an essential catalyst of the recognition process. Therefore, we develo...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2016

ISSN: 0305-1048,1362-4962

DOI: 10.1093/nar/gkw043